Pfizer Shares Fall 11% on Failure Of Cholesterol Drug

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WASHINGTON — Pfizer Inc.’s shares fell 11%, wiping out $21 billion of market value, after the world’s biggest drugmaker ended development of its most important new treatment, a cholesterol medicine designed to replace Lipitor when its patent expires.

Pfizer ended studies of the cholesterol pill torcetrapib December 2 because deaths among patients taking it were 60% higher than in a group who didn’t get the drug. The stock plunged $2.96 to $24.90 at the close of New York Stock Exchange composite trading. The shares earlier touched $23.50.

The loss of torcetrapib thrust Chief Executive Officer Jeffrey Kindler, a 51-year-old former McDonald’s Corp. executive who took the Pfizer helm in July, into one of the biggest financial crises in the New York-based company’s 157-year history. Pfizer invested $1 billion in developing the medicine and needed it to replace Lipitor, the source of a quarter of its $51 billion in annual revenue and almost half of net income.

“The bet-the-ranch-on-one-drug approach was in place before Kindler got there, so now he has a chance to change course,” an analyst with Miller Tabak & Co. in New York, Les Funtleyder, said in a telephone interview. “This announcement offers him political cover to make really radical changes.”


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