WASHINGTON — Democrats are launching a whirlwind of votes and Senate floor action Monday with the goal of confirming Judge Ketanji Brown Jackson as the first Black woman on the Supreme Court by the end of the week.

The Senate Judiciary Committee kicks off Monday morning with a vote on whether to move Judge Jackson’s nomination to the Senate floor. Democrats will then wind the nomination through the 50-50 Senate, with a final vote in sight for President Biden’s pick to replace retiring Associate Justice Stephen Breyer.

After more than 30 hours of hearings and interrogation from Republicans over her record, Judge Jackson is on the brink of making history as the third Black justice and only the sixth woman in the court’s more than 200-year history. Democrats — and at least one Republican — tout her deep experience in her nine years on the federal bench and the chance to for her to become the first former public defender on the court.

Senator Durbin, the Judiciary Committee chairman, said Thursday that the high regard for Judge Jackson after a combative four days of hearings is “evidence of the strength that she brings to this nomination and the value that she will bring to the Supreme Court.”

The Judiciary panel could deadlock on Monday’s vote, 11-11, meaning Democrats will have to spend additional hours on the Senate floor to “discharge” her nomination from committee. While it won’t delay the process for long, it’s another blow for Democrats who had hoped to confirm Judge Jackson with bipartisan support.

A deadlocked vote would be “a truly unfortunate signal of the continued descent into dysfunction of our confirmation process,” said Senator Coons of Delaware, a Democrat on the Judiciary panel.

The committee hasn’t deadlocked on a nomination since 1991, when a motion to send Justice Clarence Thomas’ nomination to the floor with a “favorable” recommendation failed on a 7-7 vote. The committee then voted to send the nomination to the floor without a recommendation, meaning it could still be brought up for a vote.

Either way, Democrats are ready to spend time on the discharge Monday afternoon, if necessary. The Senate would then move to a series of procedural steps before a final confirmation vote later in the week.

While none of the Republicans on the Judiciary panel is expected to support Judge Jackson, Democrats will have at least one GOP vote in favor on the floor — Senator Collins of Maine, who announced last week that she will support the nominee. Ms. Collins said that even though she may not always agree with her, Judge Jackson “possesses the experience, qualifications and integrity to serve as an associate justice on the Supreme Court.”

It’s unclear so far whether any other Republicans will join her. Senator McConnell set the tone for the party last week when he said he “cannot and will not” support her, citing GOP concerns raised in the hearing about her sentencing record and her support from liberal advocacy groups.

Ms. Collins and Senators Murkowski of Alaska and Graham of South Carolina were the only three to vote for Judge Jackson when the Senate confirmed her as an appeals court judge last year. Mr. Graham said Thursday he won’t support her this time around; Ms. Murkowski says she’s still deciding.

Ms. Collins’ support likely saves Democrats from having to use Vice President Harris’ tie-breaking vote to confirm Mr. Biden’s pick, and the president called Ms. Collins on Wednesday to thank her after her announcement, according to the senator’s office. The president had called her at least three times before the hearings, part of a larger push to win a bipartisan vote for his historic nominee.

It is expected that all 50 Democrats will support Judge Jackson, though one notable moderate Democrat, Senator Sinema, hasn’t yet said how she will vote.