The Department of Sanitation is proposing building a 150-foot tall garage in West SoHo, which would add over 200 vehicles and thousands of gallons of fuel to a neighborhood that’s also home to luxury condos and the site for Donald Trump’s new hotel.

While the department would not comment on the proposal until a public meeting scheduled for January 31, community leaders did not wait to voice their opposition, saying the proposal would set back the neighborhood and expose it to hazardous materials.

The director of the SoHo Alliance, Sean Sweeney, said he was particularly concerned about the garage’s refueling station. Located in a separate building closer to the Holland Tunnel, it would house nearly 30,000 gallons of fuel. “Storing flammable material so close to the tunnel would make the terrorists’ job that much easier,” he said. “Perhaps they should put a bulls-eye above it.”

Jana Haimsohn has lived on Canal Street and Washington for the past 32 years. She said that there would be “tremendous opposition” to the proposal because of its proximity to the Hudson River and a park. “We’ve always fought for this area, particularly the parks. We’re still a blossoming residential neighborhood.”

The garage would replace outdated facilities and improve efficiency by consolidating in one place branches that are now spread among Chelsea, the Upper East Side, and West SoHo, according to a departmental planning document published at the end of December. This combination would also help the department comply with its legal obligation to vacate Chelsea’s Gansevoort Peninsula sanitation facility in favor of a park, the document said.

City Council Speaker Christine Quinn, who represents the West SoHo area, had no comment on the proposal, but supports relocating the Gansevoort facility, a spokeswoman, Maria Alvarado said. As far as the impact on the neighborhood, Ms. Alvarado said that Council Member Quinn would “monitor any concerns that are raised among the community” as the plan progressed.

The garage would be situated on Spring Street between Washington and West Streets, where the United Parcel Service currently operates a package distribution facility. The department and UPS would share the proposed garage, which would be 427,000 square feet.

Each day, sanitation trucks would make 480 trips from the garage, which would operate 24 hours a day, seven days a week. The president of the Canal West Coalition, Richard Barrett, said the additional traffic would prove unhealthy. “Such a heavy consolidation in one area is an ill-conceived concept for any area in the city, but it’s especially toxic near the Holland Tunnel,” he said.

Adding to West SoHo’s recent residential growth is the influx of luxury living. The Urban Glass House, where a 10-room condo goes for $12.5 million, is located a block away from the proposed sanitation site. The site of the future Trump International Hotel & Tower SoHo, a 45-story structure that would contain 400 hotel rooms, a spa, and a high-end restaurant, is also in the vicinity. Representatives for both parties did not return phone calls.

“This is an up-and-coming neighborhood and why you’d want to blight it is beyond me,” Mr. Sweeney of the SoHo Alliance said. “People moved in with the expectation that the area was great and still improving.”