Harlem is recovering from a shooting in the heart of its business district that left six teenagers injured and the neighborhood struggling to hold onto a fledgling image of prosperity and safety.

Separate shootings elsewhere in the area on the same night left four others hurt and residents rattled.

Jackie Rowe-Adams, a lifelong Harlem resident who lost two of her sons to gun violence in the neighborhood in separate incidents years ago, said the shootings over the holiday weekend had her worried the neighborhood was slipping backwards.

“It had gotten a little better, and now it’s getting worse again,” Ms. Rowe-Adams said after attending a rally yesterday afternoon with elected officials and members of the anti-violence organization she founded, Harlem Mothers SAVE.

“Guns are flowing like water, and it’s like a river here,” she added. “Years ago the older kids had guns, and now it’s the babies.”

In a statement, the police commissioner, Raymond Kelly, said the Harlem shootings “are evidence of the apparent ease with which teens are able to acquire illegal guns and to use them without regard to the consequences.”

Harlem has seen in a spike in shootings this year even as the neighborhood has become a hub of new development. The shooting of the six teenagers at 125th Street and Lenox Avenue occurred steps away from a new luxury condo building that recently sold off all of its $1 million-plus apartments, and along a corridor that has seen a surge in commercial development, with stores such as H&M and MAC among the new arrivals.

So far this year in the 28th Precinct, which encompasses Harlem’s center, shootings have doubled to 10 — not including the incidents over the weekend.

A 15-year-old boy was arrested and charged for criminal weapons possession in the shooting of the six teenagers, and police said they were looking for two other teenage suspects.

The victims ranged in age from 13 to 18.

Police said that the shooting began at 10:10 on Monday evening, as Memorial Day barbecues in Marcus Garvey Park were ending and people were going home. Officials said an earlier shooting in the park in which no one was injured may have prompted people to leave.

Witnesses told police that they saw two or three teenage boys kneel on the southwest corner of 125th Street and begin firing up Lenox Avenue, across one of Harlem’s busiest corners.

One victim, a 16-year-old boy, dropped to the ground with a bullet wound in his pelvis. Five others were found bleeding on blocks farther north.

A 13-year-old boy was found hit in his right thigh, and a 16-year-old boy was shot in his right foot at 126th Street and Lenox. Two 17-year-olds were found at 128th Street and Lenox. One had been hit twice in the chest, the other was hit in the back. A 15-year-old girl was found just north of 125th Street on Lenox after a bullet grazed her forehead.

All were stable after being treated at St. Luke’s-Roosevelt and Harlem Hospital. The 15-year-old girl was the only one released as of yesterday evening, police said.

Police said they had found shell casings from a .380 caliber Hi-Point pistol near the spot where the suspects were seen shooting.

An hour later, a 15-year-old suspect was caught after he ran from police canvassing the area. Police said he was seen tossing a .380 caliber Hi-Point under a car as he ran.

He has denied participating in the shooting, saying he found the gun lying on the street, officials said. His name was not released because he is being charged as a juvenile.

The shooting was one of five yesterday evening across Harlem. A 20-year-old was shot and injured at Lenox Avenue and 130th Street; a 26-year-old at 201 W. 131st St.; a 39-year-old across from 300 W. 142nd St., and a 15-year-old at Seventh Avenue near 142nd Street.

Police officials said that none of the five shootings appeared to be related, and that no other arrests have been made.