Edwin O. Guthman, a Pulitzer Prize-winning journalist who was on the infamous “enemies list” prepared by aides of President Nixon and who served as press secretary to Robert F. Kennedy, has died at 89.

Guthman, who had a rare blood disease called amyloidosis, died Sunday at his Pacific Palisades home, a family spokesman, Bryce Nelson, said.

“Ed Guthman was not only a great friend, but a great journalist,” a longtime political cartoonist for the Los Angeles Times, Paul Conrad, said yesterday. “He was the only person I ever tore up a cartoon for.”

Guthman was the Los Angeles Times’ national editor between 1965 and 1977, then served for a decade as editorial page editor for the Philadelphia Inquirer.

He was awarded the Pulitzer Prize for national reporting in 1950 for his stories in the Seattle Times on the Washington Legislature’s Un-American Activities Committee. His reporting cleared a University of Washington professor of allegations that he was a communist supporter.

Guthman was press secretary for Attorney General and, later, Senator Robert F. Kennedy between 1961 and 1965.

A Kennedy loyalist in his private life, Guthman wrote or edited four books about Kennedy. And he always wore a tie clip that President Kennedy had given him, according to the USC Annenberg School for Communication.

In 1971, Guthman was the third name on a 20-name list of political opponents singled out for harassment in a memo sent from Nixon aide Charles Colson to aide John Dean.

The memo described Guthman, then national editor for the Times, as having been “a highly sophisticated hatchetman against us in ’68.”

He was a journalism professor and senior lecturer at the University of Southern California from 1987 until his retirement last year.

“He exemplifies the ultimate journalist. I’m successful because of what (he) taught me,” CNN anchor and USC alumna Kyra Phillips said during a tribute at the university last year.

Tom Brokaw praised Guthman at that tribute as one of the “greatest generation,” the USC Daily Trojan reported at the time.

“I will always see Ed Guthman as citizen Ed Guthman,” Mr. Brokaw said.

In the 1990s, Guthman was a founding commissioner and a president of the Los Angeles City Ethics Commission.

He also was one of three outside experts who reviewed — and harshly criticized — the 1993 federal standoff at the Branch Davidian compound outside Waco, Texas, in which about 80 people died.

Born August 11, 1919, in Seattle, Guthman attended the University of Washington and worked as a reporter for the Seattle Star before he was drafted in World War II. He served in North Africa and Italy, was wounded, and received the Purple Heart and the Silver Star.

Guthman is survived by three sons, a daughter, and five grandchildren.