PITTSBURGH — Nate McLouth hit a go-ahead two-run homer in the seventh, and Paul Maholm allowed two runs over eight innings as the Pittsburgh Pirates rallied to beat the Yankees 4-2 on last night.

The last game of interleague play this season was the makeup of a June 26 rainout, only with a much different beginning for Maholm (6-5). Then, he gave up extra-base hits to the first four batters as the Yankees went 5-of-12 while taking a 3-0 lead against the left-hander, only to have all the statistics wiped out by a heavy rain.

Given a chance to redo that start, Maholm had a five-hit shutout going with two outs and none on in the seventh before the Yankees tied it on Bobby Abreu’s two-run single. After McLouth hit his 18th homer to put Pittsburgh back into the lead, Maholm came back with a scoreless eighth.

Maholm, 4-0 in his last eight starts, gave up seven hits and walked one while lasting eight innings for a second successive start. Damaso Marte finished for his fourth save in six opportunities, helping end New York’s five-game winning streak.

Jack Wilson, who doubled and singled against Mike Mussina in his first two-bats as Pittsburgh’s No. 9 hitter, walked ahead of McLouth’s drive into the right-field seats against reliever Jose Veras (2-1). McLouth unsuccessfully tried to bunt on Veras’ first pitch, only to homer on the second.

The Pirates won two of three from the Yankees in interleague play, their first two victories against them since the 1960 World Series — a turnaround from past interleague results. The Yankees, 10-8 against the NL this season, are a major league-best 123-87 since interleague play began in 1997 and the Pirates, 6-9 this year against the AL, own the worst record at 63-103.

Despite the Yankees’ loss, the AL topped the NL in interleague play for a fifth consecutive season, going 149-103.