DANIA BEACH, Fla. — Playboy Playmate Anna Nicole Smith died of an accidental overdose of a sleeping medication and at least eight other prescription drugs, and she had recently had a bacterial infection from injecting drugs into her buttocks, authorities said yesterday.

Broward County Medical Examiner Joshua Perper said Smith died of “combined drug intoxication” with the sleeping medication chloral hydrate as the major factor.

She had been taking a lengthy list of medications, including methadone for pain and Valium, but those drugs were at therapeutic levels, he said. A bacterial infection from injecting medication in her buttocks and the flu contributed to her death, according to the report.

Chloral hydrate is a sedative used to treat insomnia and alcohol withdrawal, relieve anxiety, and ease post-surgery pain.

The drug is rarely prescribed and is known to be fatal if combined with certain other drugs — including the sedative Lorazepam, which the autopsy showed she was taking, said Dr. Chip Walls, a forensic toxicologist for the Miller School of Medicine at the University of Miami.

“It’s very toxic if you mix it with any other central nervous system depressant drugs,” Dr. Walls said. “You could get profound sedation leading up to coma and respiratory arrest.”

Mr. Perper said Smith also had been on several antidepressant and antianxiety drugs and had recently taken longevity medications, vitamin B12, and growth hormone. An assistant medical examiner’s report described seeing a table in Smith’s hotel room containing cold medicine, soda cans, SlimFast, nicotine gum, and an open box of Tamiflu tablets.

“We found nothing to indicate any foul play,” said Chief Charlie Tiger of the Seminole police department.

Smith, 39, was found unresponsive February 8 in her room at the Seminole Hard Rock Hotel and Casino in Hollywood on one of the tribe’s reservations.

According to the medical examiner’s report, a private nurse had asked a guard to call 911 around 1 p.m. and had started CPR. The Seminole EMS were called about 1:40 p.m. and arrived six minutes later, according to the report. The ambulance reached the hospital at 2:43 p.m., and Smith was pronounced dead shortly afterward. The reasons for the delays weren’t clear.

Mr. Tiger said authorities examined laptop computers belonging to Smith and her lawyer-turned-companion, Howard K. Stern, and found nothing unusual related to her death. Mr. Tiger also said nothing came up during an exhaustive review of tapes from hotel security cameras and from interviews with numerous witnesses.

Smith grew up in Texas and went from topless dancer to Playboy Playmate of the Year, Guess jeans model, and bride of 89-year-old oilman J. Howard Marshall II. She took her fight for Marshall’s estimated $500 million fortune as far as the Supreme Court, and the ongoing battle could make her infant daughter, Dannielynn, very wealthy. Mr. Stern and two other men have claimed to be the baby’s father.