Since his high schools days in Brooklyn, Andrew Guidone, now 28, wanted to be a director, producer, and video artist. “I always knew that was my calling,” he said yesterday. “I guess I have been relentless about my ambition.”

His ambition resulted in the creation of Python/Aquarius Productions, a film and video production company in Tribeca. Since his graduation in 1998 from the prestigious School of Visual Arts in Manhattan, Mr. Guidone has done production, camerawork, and editing for the Discovery Channel Networks, Travel Channel, the Food Network, Sony Music, Morgan Stanley, and the American Institute of Architects. He has done editing for a new PBS educational series titled “Character Studies,” featuring celebrities such as Olympia Dukakis, Phylicia Rashad, and Stephen Sondheim. Besides his corporate videos, Mr. Guidone has done hip-hop videos for Black Entertainment Television (BET).

He is also the host of a local cable series, “Arts Insight,” featuring New York neighborhood artists; his show was recently featured on London Weekend Television.

So what does it take to make in it New York? His response: “It takes dogged persistence. It’s about sharpening network skills. And in the rapidly changing media world, it’s also a matter of adaptation.”