Jane Tomlinson, who outran terminal cancer in seven inspiring years of astonishing athletic activity and fundraising for charity, died Monday at 43 at a hospital in Leeds, England.

Tomlinson continued working as a medical radiographer, ran marathons, finished one triathlon, and last year completed a bike ride across America.

Tomlinson lived with breast cancer since 1990, but being told seven years ago that she had just six month to live inspired her to become a super-athlete. Pain only seemed to spur her on.

Starting with a 10-kilometer race in 2001, Tomlinson went on to run several marathons and an Iron Man triathlon, and last year she completed a 6,780-kilometer (4,213-mile) bicycle ride from San Francisco to New York City.

She also pedaled the length of Britain in 2003 and from Rome to her home town of Leeds in 2004. Prime Minister Brown said the whole nation would be saddened by her death.

“Jane’s mission in life was a simple one: to make the most of every day and to help others, and she not only achieved that several times over, but inspired millions of others along the way,” Mr. Brown said.

Tomlinson was modest about her achievements.

“I’m not taking part to say to people, ‘Look what I can achieve.’ I’m taking part because I want to,” she said before running in the 2003 London marathon.

She raised $3.5 million for charity, her family said.

In June, Tomlinson said, “the reality is that this will probably be the last summer that I get to spend with my family.”

“I’ve had seven years to contemplate the fact that I’m not going to be around for my family but it doesn’t make that end point any clearer, I don’t think, and it doesn’t make it any easier when you meet it,” she said.