Police are searching for suspects after a teenager was shot to death early yesterday morning on the Lower East Side.

Responding to a 911 call at about 2 a.m., police found Vincent Cruz, 17, outside 205 Eldridge St. Cruz, who had been shot once in the head, was taken to Bellevue Hospital, where doctors pronounced him dead on arrival.

Police have yet to make any arrests in the ongoing homicide investigation. The incident is the first murder in the 5th Precinct this year, which includes Chinatown and parts of the Lower East Side.

Four others were killed in unrelated incidents yesterday morning and on Monday night around the city.

In Manhattan, Christopher Cruz, 19, was fatally stabbed Monday evening. Police said they believe that Cruz was involved in an argument that escalated until the man he was fighting with ran into a building on 112th Street and Second Avenue and returned with a knife, which he used to attack Cruz.

Early yesterday morning, a man whose identity has not yet been released was shot to death in a building on 150th Street off Amsterdam Avenue, in Harlem.

In the Bronx, police arrested Jermaine Elston, 29, on Monday night after he allegedly stabbed Tynel Van-Kallen, 22, multiple times in the neck and chest.

Van-Kallen, a student at Tri-County Technical College in South Carolina, was taken to St. Barnabas Hospital, where he was pronounced dead.

In Queens, Guillermo Rojas, 24, was stabbed to death late Monday night on Jamaica Avenue and 115th Street.